Funding · TechCrunch ·

Vijay Pande leaves a16z to launch AI-native VC fund VZVC

Vijay Pande left a16z's $4B biotech practice to launch AI-native fund VZVC, focusing on smaller, concentrated bets at the intersection of AI and biology.

Based on reporting by TechCrunch — analysis by dalili

Vijay Pande, who previously ran Andreessen Horowitz's roughly $4 billion biotech investment practice, has launched a new AI-native venture fund called VZVC with a deliberately smaller footprint.

Instead of placing 30 bets a year, Pande is making fewer, more concentrated investments at the intersection of artificial intelligence and biology. He argues that biology is finally transitioning from a "discovery" science to an "engineering" science, driven by AI tools that can model biological systems at unprecedented scale.

The shift reflects a broader trend of experienced investors leaving large firms to build focused, AI-first funds. Pande's deep expertise in bio-AI positions VZVC to identify companies that leverage machine learning for drug discovery, protein engineering, and synthetic biology.

The fund's smaller size is intentional — Pande believes concentrated conviction bets outperform diversified portfolios in the current AI-biology convergence.

Key takeaways

  • Vijay Pande left a16z's $4B biotech practice to launch VZVC
  • New fund is AI-native with fewer, more concentrated bets
  • Biology shifting from discovery to engineering science via AI
  • Signals maturation of AI-biology convergence for specialized capital

Why it matters

Pande's move signals that AI-biology convergence is mature enough for specialized, conviction-driven capital. When a top-tier investor leaves a $4B practice to make smaller AI-native bets, it suggests the real alpha is in deep technical expertise, not portfolio breadth.

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